Midwest funding covers Iowa, Kansas, Missouri, Nebraska, North Dakota, Oklahoma, South Dakota, Illinois, Minnesota, Ohio, and Wisconsin. With over 66 million people, the region is known for its abundant farming and manufacturing activity. Midwest venture capital firms typically provide investments ranging from $25,000 to $20 million depending on the development stage. Whether seed stage, early stage, late stage, or buyout private equity, midwest private equity is a large player nationwide and is a contributor to skyrocketing employment rates.
There is also a large presence of angel investors in the midwest region venture capital and private equity scene. Some of the industries with highest midwest capital investments include life sciences, technology, alternative energy, and clean technology. Although the region has some of the largest and most populated cities, the standard cost of living is considered lower in some areas, which can come as an advantage when looking for midwest capital.
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McCarthy Capital provides growth, recapitalization, acquisition, and buyout funding of $10 million or more to businesses with $10 million or more in annual revenue and at least $3 million in operating profit. McCarthy Capital has more than $475 million in capital under management across four funds.

Dakota Venture Group is the nation’s first student-run venture fund that focuses on regional investments and opportunities across the United States.  The fund was started at the University of North Dakota in 2006 and raises capital from benefactors and private investors.

RiverVest Venture Partners was established in 2000 and has since then invested in more than 20 early stage life sciences businesses across the nation. RiverVest Venture Partners has $164 million in invested capital spread over two funds and occasionally backs companies in their later stages.

Prolog Ventures is an early stage venture capital firm specializing in the life sciences sector.  In the past 10 years, it has invested in more than 20 businesses in traditional healthcare as well as nutrition, wellness, and green technology.

Ascension Health Ventures focuses on healthcare organizations nationwide. With $250 million under management, the firm focuses on organizations needing early to late funding with initial investments ranging up to $5 million. Ascension Heath Ventures is considered the largest nonprofit health system and backs companies in medical devices, medical/information technology, and services.

Kansas Technology Enterprise Corporation is a state-owned promoting technology innovation and job development in Kansas including in the biotechnology and clean technology sectors. The organization invests $1.5 million per year in early stage businesses with emerging products.

Advantage Capital Partners has raised more than $1.3 billion since its formation in 1992. Focusing on communities and markets with investment gaps, the firm provides debt/equity capital for diverse types of funding including growth and buyouts.

AAVIN is a private equity firm providing backing for growth, buyouts, and recapitalizations in the midwest region. Since its launch, it has invested in more than 120 companies in diverse industries including medical devices, industrial services, manufacturing, and transportation. Although AAVIN can provide anything up to $10 million, typical investments range from $500,000 to $3 million.